Consumption habits have changed significantly in the past decade, with e-commerce becoming a major player. The COVID-19 pandemic has accelerated this trend, making online shopping a popular alternative to physical stores. E-commerce relies heavily on home deliveries, which has a significant impact on the environment. To reduce these negative impacts, research focuses on optimizing e-commerce delivery and return activities. However, there is a lack of knowledge on how residential buildings and neighborhoods can accommodate e-commerce volumes while enhancing sustainability and quality. The proposed research aims to address this gap through a mixed-methods design that surveys consumers and experts in spatial planning and goods mobility. The goal is to develop a strategy for optimizing e-commerce deliveries and returns in residential areas, taking into account the urban-rural continuum and environmental impacts of different supply chains.